MOTS-c, 10mg
54,89 €
Note: The analytical batch certificates (COAs) for MOTS-c are available in the COA-gallery.They are updated regularly to reflect the latest verified purity and composition of each production batch.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-encoded, 16-amino-acid peptidefirst described in 2015. It represents a class of mitochondrial-derived signaling peptides (MDPs) that extend mitochondrial function beyond bioenergetics, acting as retrograde messengers between mitochondria and the nucleus. In laboratory research, MOTS-c is examined for its role in metabolic regulation, insulin sensitivity, and cellular stress adaptation. During energetic or oxidative stress, the peptide translocates to the nucleus, influencing gene networks involved in glucose utilization, fatty-acid metabolism, and antioxidant response.
Mechanistic Scope
Metabolic Regulation: Enhances AMPK-linked pathways to balance glucose and lipid metabolism.
Insulin Sensitivity: Modulates cellular uptake and mitochondrial efficiency in metabolic models.
Exercise Endurance: Associated with improved skeletal-muscle adaptation and fatigue resistance.
Cellular Stress Response: Participates in nuclear signaling that supports oxidative-stress tolerance.
Aging Research: Investigated for its impact on mitochondrial–nuclear communication and proteostasis.
MOTS-c acts as a mitochondrial hormone analog, bridging the gap between energy production and genomic control — a central concept in current studies of metabolic resilience and healthy aging.
Formuly Labs supplies MOTS-c in high-purity lyophilized form, suitable for controlled laboratory work. Each batch undergoes HPLC and mass-spectrometric verification with documented purity typically exceeding 99 %.Lot-specific certificates confirm identity, composition, and analytical performance parameters.
For laboratory research only. Not for human or veterinary use.
Quantity
Product Information
| sequence |
Met-Arg-Trp-Gln-Glu-Met- Gly-Tyr-Gln-Glu-Lys-Phe- Arg-Pro-Arg-Asn-NH₂ |
| length (aa) | 16 |
| molecular formular |
C₁₆₅H₂₆₀N₄₆O₄₆S₂ |
| molecular weight |
2171.47 Da |
| source |
Synthetic (SPPS) |
| form | Lyophilized powder |
| synonyms |
Mitochondrial ORF-encoded peptide MOTS-c; MDP-16 |
Handling & Storage
- Store at or below −20 °C in a dry environment.
- Reconstitute immediately prior to use with peptide-grade solvent.
- Avoid repeated freeze-thaw cycles to maintain molecular integrity.
Summary
MOTS-c provides researchers with a defined model for studying mitochondrial–nuclear communication, metabolic homeostasis, and stress adaptation mechanisms.
Through precise synthesis, verified analytical documentation, and high-purity standards, Formuly Labs enables rigorous exploration of emerging mitochondrial signaling biology.